Organoid Research Antibodies & Growth Factors
Organoid research utilizes three-dimensional culture systems developed from stem cells or primary tissues to replicate organ development and disease processes. Patient-derived tumoroids extend this approach by enabling the study of individual tumors and their responses to therapeutic interventions in a physiologically relevant setting. These models mimic essential features of tissue structure and function, allowing for physiologically relevant studies in vitro.
The antibodies and proteins in this category are designed to support the generation, characterization, and use of organoids and tumoroids in disease modeling and drug discovery. R-spondins (offered here as human and mouse RSPO1 in both His-tagged and Fc-fusion formats, plus an Rspo3-Fc conditioned medium) are potent amplifiers of Wnt signaling. The WNT Surrogate-Fc fusion protein provides a stable, fully recombinant alternative to conventional Wnt3a-conditioned medium, giving more defined and reproducible Wnt input. The Noggin-Fc fusion protein conditioned medium antagonizes BMP signaling. Together, an R-spondin / Wnt / Noggin combination (conveniently bundled in the organoid growth factor starter package) reconstitutes the core stem-cell niche and improves batch-to-batch consistency, a recurring challenge in organoid culture.
Featured products: Noggin (recombinant Noggin-Fc) and R-spondin 3 (Rspo3-Fc) — growth factors widely used for intestinal, liver, and tumor organoid culture.