WNT Surrogate-Fc Fusion Protein
WNT Surrogate-Fc Fusion Protein
The Wnt signaling pathway is essential for embryonic development, stem cell differentiation and regeneration of injured tissues. Wnts hetero-dimerize Frizzled (Fzd) family receptors and their co-receptors Lrp5/6, triggering downstream signaling pathways including the canonical β-catenin cascade, and resulting in expression of genes regulating cell development. Due to its critical roles in development, Wnt has been widely used as an essential cell growth factor in organoids, a rapidly developing model system for tissue development. Currently, recombinant Wnt3a is commonly used as Wnt source. Unfortunately, recombinant Wnt3a is water insoluble and cannot serve as a medium supplement. Recombinant Wnt Surrogate-Fc Fusion-protein has an excellent solubility, and a better wnt response at lower effective concentrations than other sources of Wnt3a. WNT Surrogate-Fc Fusion-protein supports longterm expansion of multiple different types of organoids, including intestinal, kidney, colon, hepatocyte, ovarian, and breast organoids.
Production platform: This product is produced in HEK293 cells using the rPEx® recombinant protein production platform.
New user exclusive offer: Receive a 60% discount on 25 µg (trial size) of WNT Surrogate-Fc fusion protein. € 85 (excluding tax and shipping). Send your request to products@avsbio.com (Offer limited to one per new user). The product is covered by US patent (application) 62/698,576.
