Platelet Derived Growth Factor Βeta, Human

Platelet Derived Growth Factor B, Human
Human PDGFb, platelet derived growth factor, is a dimeric protein. It can form homodimers of PDGFb or heterodimers with PDGFa. It is involved in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Mutations in PDGFb are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor.

Production platform: This product has been produced in HEK293 cells using the rPEx® recombinant protein production platform.