MART1, human

MART1, Human
The expression of Mart1 is restricted to the retina, melanomas and melanocyte cell lines. It is involved in melanosome biogenesis by ensuring the stability of GPR143 and plays a vital role in the expression, stability, traficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes. Intracellular it is found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.

Production platform: This product has been produced in HEK293 cells using the rPEx® recombinant protein production platform.