Mouse anti-sheep IgE

Mouse anti-sheep IgE
Antibody against sheep IgE. IgE is an immunoglobulin primarily produced from plasma cells. In normal serum it is present at very low concentrations. Western blot analysis against affinity purified ovine IgE using this antibody demonstrates a single major band of approximately 80 kDa or 200 kDa under reducing and non-reducing conditions, respectively. These bands correspond with the expected molecular weights of the epsilon chain and the complete ovine IgE molecule. IgE is important in both type 1 hypersensitivity and immunity to parasite infections, in particular parasitic worm infections. This antibody has been used in a number of studies involving parasite nematode infections of sheep by Haemonchus contortus. It also recognizes bovine IgE, and as such it is useful for studies of infection in cattle by nematode worms.