CD45-ECD_(AVI/Biotin-his)C, human

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Complement C5A, Human
CD45-ECD_(AVI/Biotin-his)C, human in this product is the longest isoform of CD45 and contains all N-terminal domains A, B and C that are encoded by exon 4, 5 and 6. The protein contains a C-terminal biotinylated AVI-tag followed by a hexahistidine-tag. CD45 plays a central role in immune cell signalling by regulating the phosphorylation state of Src-family kinases such as Lck, Fyn, and Lyn. Through this activity, CD45 is essential for antigen receptor-mediated activation, proliferation, differentiation, and function of both T- and B- lymphocytes. Altered CD45 expression or signalling has been associated with immunodeficiency, autoimmunity, leukaemia, and lymphoma.

Production platform: This product has been produced in HEK293 cells using the rPEx® recombinant protein production platform.

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