Mouse anti-human BChE

Mouse anti-human BChE
Antibody against butyrylcholinesterase (BChE), also known as pseudocholinesterase, is a disulfide linked tetrameric enzyme produced by the liver and also found in the blood circulation. Its function is not fully understood but it is known to hydrolyze a range of (choline) esters and therefore important for the detoxification of drugs and toxins including the muscle relaxant succinylcholine and several pesticides. In the healthy brain, cholinesterase is mainly responsible for regulating acetyl choline levels while BChE plays a minor role. In contrast, BChE activity is reported to be increased in Alzheimer’s disease patients and it was suggested that selective inhibition of BChE could have a therapeutic effect.