Arthritis Antibody Mix

Arthritis Antibody Mix
Collagen-induced arthritis is an antibody mediated disease. Therefore, type II collagen specific antibodies can be used to induce arthritis. Our mixture of type II collagen specific antibodies (2.4 mg per animal) induces severe inflammation in the ankle and paws of DBA mice which resemble many aspects of arthritis. A dose titration of the antibodies showed that the lowest dose (0.8 mg) showed arthritis in 33.3% of the mice which increased to 83.3% after LPS injection . One of the biggest advantages of our monoclonal antibody-induced (mAb) arthritis model is that severe arthritis is induced within 24-48 hours instead of the four weeks required to induce arthritis after immunization with type II collagen. AVS Bio recommends highly susceptible DBA/1 mice. Other strains may be used, however the amount of antibody cocktail may vary. The current CAIA model is ideal for rapidly screening therapeutics for the treatment of arthritis and to study the mechanisms involved in the development of arthritis.